Subject
Physiology
Cellular organisation, ATP, membrane transport, membrane potentials, signalling and injury.
Oxygen transportThe oxygen cascade, content and delivery, the dissociation curve and V/Q matching, with an interactive laboratory.
CardiovascularThe cardiac cycle, pressure–volume relationships and the control of output.
Cardiac electrical activityVentricular and nodal action potentials, the ionic currents behind each phase, and where antiarrhythmics act.
Subject
Pharmacology
Exponential decay from first principles, absorption and ionisation, volume of distribution, clearance and extraction.
Pharmacokinetics 2 — kinetics and modelsMichaelis–Menten kinetics, compartment models, infusions and the BET scheme, context-sensitive half-time and TCI.
Pharmacokinetics 3 — special populationsPregnancy, paediatrics, the elderly, obesity and critical illness, with worked calculations.
Antiemetics 1 — the reflex and prophylaxisThe vomiting centre and the chemoreceptor trigger zone, the five afferent routes and the receptor each carries, the risk scores, and a risk-stratified prophylaxis algorithm.
Antiemetics 2 — the receptor antagonists5-HT3, dopamine, histamine and muscarinic antagonists, with every adverse effect derived from where the blocked receptor sits.
Antiemetics 3 — steroids, NK1 and combinationsDexamethasone and its unsettled mechanism, the NK1 antagonists, the adjuncts, and the arithmetic of combination and rescue therapy.
Subject