Anaesthesia Notes

01

Pharmacokinetics

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First-order elimination: rate constant, time constant and half-lifeOpen lesson

Absorption, ionisation, pKa and ion trappingOpen lesson

Bioavailability, AUC and the extraction ratioOpen lesson

Explain volume of distribution, its determinants and plasma protein bindingOpen lesson

Clearance, and flow- against capacity-limited eliminationOpen lesson

Hepatic metabolism, cytochrome P450, and renal drug handlingOpen lesson

Michaelis–Menten kinetics; zero- and first-order eliminationOpen lesson

Draw and explain one-, two- and three-compartment models, and the BET infusion schemeOpen lesson

Explain the effect site, keo, hysteresis and context-sensitive half-timeOpen lesson

Compare the Marsh, Schnider, Minto, Paedfusor and Eleveld TCI modelsOpen lesson

Altered pharmacokinetics in pregnancy, children, ageing, obesity and critical illnessOpen lesson

The standard pharmacokinetic calculationsOpen lesson

02

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03

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04

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Cholinergic, anticholinergic and organophosphate pharmacology

Adrenergic agonists, antagonists and monoamine oxidase inhibitor interactions

Antihypertensives, vasoactive drugs, cardiac glycosides and antiarrhythmics

Histamine, antihistamines and phenothiazines

Oxytocics and prostaglandins

Diuretics, antimicrobials, endocrine drugs and corticosteroids

Anticoagulants, antagonists, fibrinolytics and antifibrinolytics